Lot-to-Lot Variations in a Qualitative Lateral-Flow Immunoassay for Chronic Pain Drug Monitoring

Lot-to-lot variations in a qualitative lateral-flow immunoassay for chronic pain drug monitoring.

Recently, Algeciras-Schimnich et al. highlighted the lot-to-lot variability of a quantitative immunoassay and the failure of frequently used protocols to detect these variations (1). We have discovered that lot-to-lot variations also present an important issue in qualitative immunoassays used for chronic pain monitoring. These variations impact the reliability of these assays in clinical practi...

Simultaneous Lot Sizing and Scheduling in a Flexible Flow Line

This paper breaks new ground by modelling lot sizing and scheduling in a flexible flow line (FFL) simultaneously instead of separately. This problem, called the ‘General Lot sizing and Scheduling Problem in a Flexible Flow Line’ (GLSP-FFL), optimizes the lot sizing and scheduling of multiple products at multiple stages, each stage having multiple machines in parallel. The objective is to satisf...

How to Use MRP in Continuous Production Industries When Order Type is Lot for Lot

The Materials Requirements Planning (MRP) method that is applied in production planning and management has some weaknesses. One of its weaknesses is that the time in MRP method is discrete, and is considered as time period. Hence we are not able to order our requirements at irregular time moments or periods. In this paper, a new form of MRP is introduced that is named Continuous Materials Requi...

More on lot-to-lot changes.

A Basic Period Approach for Solving the Economic Lot and Delivery Scheduling in Flexible Flow Lines

In this paper, the problem of lot sizing, scheduling and delivery of several items in a two-stage supply chain over a finite planning horizon is studied. Single supplier via a flexible flow line production system (FFL), produces several items and delivers them directly to an assembly facility. Based on basic period (BP) strategy, a new mixed zero-one nonlinear programming model has been develop...